Calcium L-5-Methyltetrahydrofolate, the active form of folic acid, has shown promising benefits in weight management, specifically in reducing abdominal fat. A 2019 study found that while not affecting overall weight, folic acid notably decreased abdominal fat percentages.

This effect arises from folic acid's ability to slow liver fat production and hinder the growth of new fat cells - specifically those in the abdomen (belly fat in other words).

Thus, while weight may remain constant, body composition can shift towards less abdominal fat.

Vitamin B12 plays a crucial role in weight loss and overall health, especially for those who have undergone bariatric surgery. A study found that despite taking prescribed supplements, 80.7% of patients had at least one nutritional deficiency, with Vitamin B12 being a common shortfall.

This deficiency was particularly prevalent in women. To counteract this, the study recommends a daily supplement of 1 mg of oral Vitamin B12.

This not only aids in weight loss but also prevents potential irreversible neurological damage that can occur from a deficiency.

Chromium Picolinate and Chromium Nicotinate Glycinate Chelate are compounds of chromium created to drastically increase bioavailability. This means the chromium in Zmyra is much more readily absorbed than the chromium found in food.

Chromium is one of the best natural weight loss supplements in existence. In simple terms, Chromium plays a crucial role in enhancing the action of insulin, a hormone critical to the metabolism and storage of carbohydrates, fats, and proteins in the body.

When combined with the other ingredients in Zmyra, it delivers significant appetite reduction.

L-Carnitine Tartrate, a key player in fat metabolism, can accelerate fat burning and potentially aid in weight loss, as per a study by Xiaotian Liu. This compound transports fatty acids into the mitochondria where they undergo β-oxidation, providing energy for the body. However, the study emphasizes that L-Carnitine alone isn't an ideal choice for weight loss

Its effectiveness is more pronounced in overweight and obese individuals when combined with substantial exercise.

It’s important to note that these benefits were most significant.

Alpha-Lipoic Acid (ALA) is a potent antioxidant that has been shown to aid in weight loss. A study involving 100 obese adults found that ALA supplementation, combined with Faradic (an electrical stimulating system), significantly reduced weight, body mass index (BMI), body fat, and waist circumference. 

The study suggested that ALA and Faradic may work synergistically to promote weight loss, possibly through changes in serum levels of various biomarkers

ALA is naturally found in foods such as meat, spinach, and broccoli, and plays a crucial role in mitochondrial energy metabolism.

Caffeine anhydrous is essentially a dehydrated form of caffeine, and it's a popular ingredient in many dietary supplements, especially those targeting energy and weight loss. From a metabolic perspective, caffeine anhydrous is known to give a boost to our metabolic rate, which translates into our bodies burning calories at a faster rate, even at rest. This enhanced calorie burn can be a useful ally in weight management. 

Moreover, it can also enhance physical performance by increasing adrenaline levels, thereby potentially leading to more effective workouts. Another benefit is its role as an appetite suppressant, which can make those on a diet feel less hungry, reducing the urge to snack.

Capsaicin, the compound that gives chilli peppers their heat, has been shown to aid in weight maintenance and fat oxidation, according to a study published in the British Journal of Nutrition. The study involved subjects who had lost weight and were divided into two groups, one receiving capsaicin supplements and the other a placebo.

While both groups regained some weight, the capsaicin group showed a smaller increase in respiratory quotient, indicating less decrease in fat oxidation. In fact, fat oxidation after weight maintenance was higher in the capsaicin group.

Glucomannan, a water-soluble dietary fiber derived from the root of the konjac plant, it's an extremely effective weight loss supplement thanks to its ability to reduce appetite, stave off hunger and eliminate food cravings. Glucomannan’s unique ability to absorb water and expand in the gastrointestinal tract creates a feeling of fullness, which can help control appetite and reduce calorie intake.

 This fiber supplement also has the potential to improve cholesterol and blood sugar levels, contributing to overall metabolic health. Glucomannan is typically much more effective.